SOCIETÀ ITALIANA DI BIOCHIMICA
E BIOLOGIA MOLECOLARE
FEDERATION OF EUROPEAN BIOCHEMICAL SOCIETIES
UNIVERSITÀ DEGLI STUDI DI PAVIA
36a Riunione Nazionale “A. Castellani”
dei Dottorandi di Ricerca in Discipline Biochimiche
(36th “A. Castellani” Meeting of PhD students in biochemical sciences)
BRALLO DI PREGOLA (Pavia)
25-29 May 2026
PROGRAM
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MONDAY, MAY 25, 2026
17.00-20.00 Registration & check-in
20.00 DINNER
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TUESDAY, MAY 26, 2026
8.50-9.00 Opening remarks
9.00-9.50 Prof. Irene Díaz-Moreno (University of Seville)
Biomolecular condensates: a newfound source of cellular order in life and disease
9.50-10.15 Antonio Matrone (Università de L’Aquila)
Pyrroloquinoline quinone (PQQ) protects human trabecular meshwork (HTM) from dexamethasone-induced dysfunction: effects on cell migration, cytoskeleton and mitochondrial homeostasis
10.15-10.40 Milena Putnik (Università di Padova)
The voltage-gated potassium channel Kv1.3 functions as a signaling platform regulating protein synthesis
COFFEE BREAK
11.10-11.35 Jan Hurdálek (University of Hradec Králové)
Extracellular PDZ-binding motifs – explore, explain, exploit
11.35-12.00 Antonia Cugliari (Università di Bologna)
Dual functional behavior of F1Fo-ATPase: differential regulation by Mg²⁺ and Ca²⁺ and modulation by small molecules
12.00-12.25 Beatrice Ghezzi (Università del Piemonte Orientale)
Extracellular NAMPT and NNMT characterize BRAF inhibitor–resistance in melanoma cells, with preliminary evidence of nuclear localization
13.00 LUNCH
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15.00-15.50 Prof. Domenica Scumaci (Università Magna Græcia, Catanzaro)
Epigenetics and metabolism: novel vulnerabilities in the fight against cancer
16.00-17.00 BLITZ PRESENTATIONS (A)
1 Alessandro Cinquantini (Università di Brescia)
At the crossroad between membrane receptor signaling and cytoskeleton remodeling
2 Matilde Giusti (Università di Firenze)
Bidirectional neutrophil extracellular traps and sphingosine-1-phosphate crosstalk orchestrates fibrotic progression in endometriosis
3 Giacomo Bruno (Università di Pavia)
ER-phagy modulation as new approach to treat Osteogenesis Imperfecta: an in vivo study
4 Anam Aftab (Università Magna Græcia, Catanzaro)
Targeting glutamine metabolism to enhance sensitivity to ATR inhibition in triple-negative breast cancer cells
5 Ilaria Tagliabue (Università di Milano)
Lipid remodelling and neurogeneration in a human midbrain organoid model of GCase deficiency
6 Ilenia Boccadoro (Università di Teramo)
Intestinal and blood–brain barrier permeability in autism spectrum disorder
COFFEE BREAK
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20.00 DINNER
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WEDNESDAY, MAY 27, 2026
9.00-9.50 Prof. Luigi Palmieri (Università di Bari Aldo Moro)
The mitochondrial carrier family: a long journey from bioenergetics and protein chemistry to human health and industrial biotechnology
9.50-10.15 Giacomo Cimino (Università de L’Aquila)
Early neuroinflammation and FAAH inhibition in the Tg2576 model of Alzheimer’s disease
10.15-10.40 Jessica Ferrigno (Università di Catania)
The MK-MSC synapse as a driver of stromal dysfunction and fibrosis in myeloproliferative disorders
COFFEE BREAK
11.10-11.35 Martina Contestabile (Università di Pisa)
Protective effects of urolithin derivatives in an in vitro model of neuronal aging
11.35-12.00 Konstantinos Partsinevelos (Università di Catania)
Metabolomic response of A172 glioblastoma cells to focused sonoporation
12.00-12.25 Federica Carnemolla (Università di Firenze)
S100A8 and S100A9 proteins drive neuroinflammation: protective effects of oleuropein aglycone and hydroxytyrosol
13.00 LUNCH
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15.00-15.50 Prof. Valentina Audrito (Università del Piemonte Orientale)
The impact of NAMPT/NAD axis in supporting progression, drug resistance and tumor-host crosstalk in metastatic melanoma and malignant pleural mesothelioma
16.00-17.00 BLITZ PRESENTATIONS (B)
1 Joshua Grana (Università di Milano)
Proteomic mapping of brain aging in sheep reveals region- and sex-dependent differences
2 Karin Manco (Università di Napoli Federico II)
Integrative multi-omics profiling of pathophysiologic signatures in methylmalonic acidemia and homocystinuria CblC type
3 Filippo Piccoli (Università di Verona)
Mutant p53 drives glycolytic rewiring and protein lactylation in pancreatic ductal adenocarcinoma
4 Carola Pedroli (Università di Milano)
Biochemical and functional characterization of a β4GalNT1 knock-out murine neuroblastoma cell model
5 Giacomo Venditti (Università di Firenze)
Deregulation of mitochondrial metabolism and NAD homeostasis during prostate cancer cell detachment
6 Filippo Zuanetti (Università di Verona)
Strategies to obtain active oligomers of the antitumor ribonuclease onconase: preliminary data
COFFEE BREAK
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20.00 DINNER
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THURSDAY, MAY 28, 2026
9.00-9.50 Prof. Massimo Donadelli (Università di Verona)
Chemoresistance and molecular alterations driven by mutant p53 in pancreatic cancer
9.50-10.15 Ilenia Paoletti (Università di Foggia)
β-hydroxybutyrate as a modulator of human hippocampal neurogenesis and cognitive function: from in vitro mechanisms to in vivo outcomes
10.15-10.40 Marilena Palomba (Università della Campania Luigi Vanvitelli)
Molecular interaction between microRNA-423-5p and the long non-coding RNA PVT1, and development of innovative nanovectors for hepatocellular carcinoma therapy
COFFEE BREAK
11.10-11.35 Gaia Galassi (Università di Milano)
HDAC6 and HDAC8 combined targeting to counteract Glioblastoma Multiforme progression and treatment resistance
11.35-12.00 Giuseppe Nicolò Conti (Università di Catania)
Characterization of isoform switching associated with bortezomib resistance in multiple myeloma by long-read RNA sequencing
12.00-12.25 Marta Bastiani (Università di Siena)
BPGM enzyme supports cancer-associated fibroblast proliferation and sustains cancer growth
13.00 LUNCH
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15.00-15.50 Prof. Mauro Magnani (Università di Urbino Carlo Bo)
Cell-based therapeutic interventions in A-T patients
15.50-16.15 Susan Mirmajidi (Università di Milano)
Circulating signaling lipid profiling in maternal obesity and gestational diabetes
16.15-16.40 Giacomo Cappella (Università di Roma La Sapienza)
Two shorter variants of the proline-rich antimicrobial peptide B7-005 scaffold active against clinical isolates of Pseudomonas aeruginosa and Staphylococcus aureus
16.40-17.05 Francesco Giaretto (Università di Torino)
Structural characterization of the chimeric enzyme CYP-SOX by pulsed EPR spectroscopy
COFFEE BREAK
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17:30-18:00 Getting to know FEBS activity
Prof Mauro Magnani, University Urbino Carlo Bo; Chair, FEBS Executive Committee
Prof. Irene Diaz-Moreno, University of Seville; Chair, FEBS Excellence Awards and Fellowships Committee
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20.00 DINNER
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21.00-23.00 Serata caminetto
Assessing the value of Science and Scientists: a very challenging issue
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FRIDAY, MAY 29, 2026
9.00-9.50 Prof. Ruggero De Maria (Università Cattolica del Sacro Cuore, Roma)
Development of therapeutic antibodies and CAR T cells targeting cancer stem cells
9.50-10.15 Valentina Bonaldi (Università di Pavia)
Phosphatidylinositol 3-kinase regulates the biogenesis of platelet-derived extracellular vesicles
10.15-10.40 Soulef Bouakkaz (Università di Genova)
Establishing a chapter in the context of the quality management system at the Centro Risorse Biologiche of the AOM IRCCS Ospedale Policlinico San Martino
10.40 CLOSING REMARKS
11.00 DEPARTURE
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SCIENTIFIC AND ORGANIZING COMMITTEE Vittorio Bellotti Antonella Forlino Antonio Rossi Giampaolo Minetti Maria Enrica Tira Mauro Torti Andrea Bellelli Santina Bruzzone Giovanni Li Volti Riccardo Miggiano
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SCIENTIFIC AND ORGANIZING SECRETARIAT Università degli Studi di Pavia Dipartimento di Biologia e Biotecnologie “Lazzaro Spallanzani” Laboratori di Biochimica Via Agostino Bassi, 21 - 27100 PAVIA E-mail: riundott@unipv.it - Homepage: https://bralweb.unipv.it ~-~-~-~-~-~-~-~-~-~~-~-~-~-~-~-~-~-~-~-~~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~