35a Riunione Nazionale
“A. Castellani”
dei Dottorandi di Ricerca in
Discipline Biochimiche
(35th “A. Castellani” Meeting of PhD students in biochemical sciences)
BRALLO DI PREGOLA (Pavia)
3-7 June 2025
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PROGRAM
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TUESDAY, JUNE 3rd, 2025
17.00-20.00 ARRIVAL AND REGISTRATION
20.00 DINNER
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WEDNESDAY, JUNE 4th, 2025
8.50-9.00 OPENING OF THE MEETING
9.00-9.40 Prof. Michela Tonetti (Università di Genova)
Development of a TGDS knockout zebrafish model for studying the pathogenesis of Catel-Manzke syndrome
9.40-10.00 Maria Teresa Altieri (Università di Ferrara)
Exploring the TNPO3 influence in LGMDD2 zebrafish model
10.00-10.20 Elisa Zamprogno (Università di Udine)
Unraveling the correlation between dystonia and autophagic flux via ATP5CM3 mutations
COFFEE BREAK
10.50-11.10 Giorgia Guccione (Università di Genova)
Tackling the NAD-related signaling pathways to counteract doxorubicin-induced cardiotoxicity
11.10-11.30 Michela Rosiello (Università di Foggia)
Clockwork cells: circadian control of mitochondrial functions
11.30-11.50 Mirko Tamma (Università di Foggia)
Circadian mitochondrial dysfunction in cellular models of early-onset Parkinson’s disease with PARK2 mutations
11.50-12.10 Camilla Maggi (Università di Brescia)
VEGFR2 R1051Q mutation modifies receptor membrane behavior and cellular metabolism through heterodimerization
13.00 LUNCH
15.00-15.40 Prof. Mauro Maccarrone (Università dell’Aquila)
Phytocannabinoids, Endocannabinoids and The Challenge of Developing Selective Drugs
15.40-16.00 Camilla Danisi (Università di Napoli Federico II)
The CAM assay: an in vivo model to evaluate the biocompatibility and the efficacy of novel therapeutic compounds
16.00-16.20 Gianluca Morganti (Università di Urbino)
Development of a surface-modified LNP with the aim of crossing the BBB and releasing ATM-variant mRNA into neuronal cells
COFFEE BREAK
16.50-17.10 Prof. Mauro Maccarrone (FEBS Chair of the Advanced Courses Committee)
FEBS Contribution to the Advancement of Molecular Life Sciences
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20.00 DINNER
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21.00-23.00 Serata caminetto
La collaborazione e la ricerca scientifica internazionale in tempi di guerra
Interverranno: Prof. Vittorio Bellotti (Università degli Studi di Pavia)
Prof. Salvatore Zappalà (Università degli Studi di Catania)
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THURSDAY, JUNE 5th, 2025
9.00-9.40 Prof. Adriano Aguzzi (Universitätsspital Zürich, CH)
Functional Genomics of the Prion Life Cycle
9.40-10.00 Irene Balloni (Università di Pisa)
Investigation of the role of the 18 kDa translocator protein in neuroprotection: new modulatory mechanisms in different neuronal models of Alzheimer’s disease
10.00-10.20 Gloria Basso (Università di Pisa)
Adenosine in an in vitro model of lung fibrosis: focus on its effects in myofibroblast-lipofibroblast trans-differentiation
COFFEE BREAK
10.50-11.10 Tatiana Zuppelli (Università di Catania)
Lipocalin-2 and iron metabolism dysregulation promote glioblastoma progression and resistance to radiotherapy
11.10-11.30 Mario Cocorullo (Università di Pavia)
Targeting Mycobacterium abscessus salicylate synthase to disrupt iron acquisition mechanisms employing FDA-approved drugs
11.30-11.50 Chiara Motta (Università di Pavia)
A Novel Virulence Mechanism in Staphylococcus aureus: FnBPA Cross-Linking to Fibrinogen by Bacterially Activated FXIII and TG2
11.50-12.10 Serena Rustichelli (IUSS, Pavia)
Natural modulators of platelet activation: antithrombotic potential of curcumin and its analogues
13.00 LUNCH
15.00-15.40 Prof.ssa Lucia Longhitano (Università di Catania)
Zebrafish (Danio rerio): a model for exploring metabolic rewiring in human diseases
15.40-16.00 Giorgia Casucci (Università di Genova)
Effects of TGDS knockdown in ATDC5 cells’ chondrogenic differentiation
16.00-16.20 Alessandra Sala (Università di Pavia)
Development of therapeutic approaches to treat osteogenesis imperfecta
16.20-16.40 Aghna Maryam (Università di Urbino)
Protective role of nutraceuticals against UV-induced damage in human keratinocytes
COFFEE BREAK
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17.10-18.00 BLITZ PRESENTATIONS (A)
1 Susan Mirmajidi (Università di Milano)
Placental endocannabinoid and eicosanoid profiling in maternal obesity and gestational diabetes
2 Sofia Paola Lombardo (Università di Catania)
Safety and efficacy profiling of sonoporation as a drug delivery method in solid tumors
3 Anam Aftab (Università di Catanzaro Magna Grecia)
Targeting glutamine metabolism to enhance sensitivity to ATR inhibition in triple-negative breast cancer cells
4 Greta Bertoli (Università di Siena)
Understanding prostate cancer organotropism: the role of citrate in the interplay between lung and bone resident cells and metastatic prostate cancer cells
5 Giuseppe Nicolò Conti (Università di Catania)
Long-reads RNAseq reveals an isoform switching transcriptional landscape in irradiated microglia
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20.00 DINNER
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FRIDAY, JUNE 6th, 2025
9.00-9.40 Prof.ssa Marzia Perluigi (Università di Roma La Sapienza)
Defects of redox homeostasis and bioenergetics in the brain: a dangerous interplay for cognitive decline
9.40-10.00 Laura Orlando (Università di Catania)
Proteomic analysis profile and oxidative stress in glioblastoma cells exposed to radiotherapy
10.00-10.20 Federico Marchini (Università di Siena)
Cystine-dependent metabolic vulnerabilities in mesenchymal stem-like triple-negative breast cancer: role of NRF2 and EGLN1 in oxidative stress resistance
COFFEE BREAK
10.50-11.10 Nicola Masè (Università di Verona)
Molecular Insights into Redox-Mediated Regulation of a Toxoplasma gondii Cyclophilin
11.10-11.30 Clelia Cortese (Università di Siena)
HPLC and MALDI-TOF analysis of promising new antimicrobial peptides for stability assessment against specific protease activity at infection sites
11.30-11.50 Angelo Sparti (Università di Urbino)
Investigating the therapeutic potential of a novel fully human IgG4 anti-CD99 antibody through functional and phenotypic characterization in acute myeloid leukemia and immune cells
11.50-12.10 Enrico La Spina (Università di Catania)
Tumour Neutrophyls Mitochondrial Dysfunction and SYK/STAT5/NLRP3 Activation in Myelofibrosis: Impact of Ruxolitinib on NETs Formation and Bone Marrow Inflammation
13.00 LUNCH
15.00-15.40 Prof. Luca Bini (Università di Siena)
Extensive Proteomic Approach: a tool to open new perspectives in the study of viral infections
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17.00-18.00 BLITZ PRESENTATIONS (B)
1 Martina Codibue (Università di Brescia)
Gremlin-1 promotes the acquisition of an inflammatory, oxidative and mesenchymal phenotype in 3T3-L1-derived adipocytes possibly via BMP-independent molecular pathways
2 Stefano Putaggio (Università di Messina)
Impact of catechin and epicatechin on AE1 functionality of human red blood cells
3 Elisa Moreschi (Università di Brescia)
Development of polypyrrole-based actuator to deepen the effects of tumoral extracellular matrix remodeling on endothelial cells
4 Ilenia Paoletti (Università di Foggia)
Exploring the effects of β-hydroxybutyrate on a new in vitro model of human hippocampal neurogenesis
5 Gabriele Paolozzi (Università di Roma La Sapienza)
Quantitative proteomics reveals BVRA as a key protein in mitochondrial metabolism
6 Federica Di Padua (Università di Ferrara)
Anti-inflammatory effects of S-1-propenyl-L-cysteine, a major costituent of aged garlic extract: reversion of the proinflammatory mRNA up-regulation induced in human bronchial epithelial IB3-1 cells by the COVID-19 BNT162b2-vaccine
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COFFEE BREAK
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20.00 DINNER
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SATURDAY, JUNE 7th, 2025
9.00-9.40 Prof. Alessando Prinetti (Università di Milano)
Cross talk between different cell populations in myelin repair: sphingolipids conduct the orchestra
9.40-10.00 Cosimo Damiano Perrone (Università di Siena)
SNIPR-driven orthogonal genetic circuits for tumor-specific sensing in lymphocytes
10.00-10.20 Wendy Pérez Franco (Università di Pavia)
Unrevealing the multi-organ consequence of osteogenesis imperfecta in aging
10.20-10.40 Asifa Khan (Università di Pavia)
Insights in the musculoskeletal phenotype of an animal model of diastrophic dysplasia
10.40 CLOSING REMARKS
11.00 DEPARTURE
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SCIENTIFIC AND ORGANIZING COMMITTEE Vittorio Bellotti Antonella Forlino Antonio Rossi Giampaolo Minetti Maria Enrica Tira Mauro Torti Santina Bruzzone Giovanni Li Volti Chiara Schiraldi -~-~-~-~-~-~-~-~~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~ SCIENTIFIC AND ORGANIZING SECRETARIAT Università degli Studi di Pavia Dipartimento di Biologia e Biotecnologie “Lazzaro Spallanzani” Laboratori di Biochimica Via Agostino Bassi, 21 - 27100 PAVIA E-mail: riundott@unipv.it - Homepage: http://www.unipv.it/bralweb ~-~-~-~-~-~-~-~-~~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~-~