30^a Riunione Nazionale
“A. Castellani”
dei Dottorandi di Ricerca in
Discipline Biochimiche

BRALLO DI PREGOLA (Pavia)

4-8 GIUGNO 2018

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SCIENTIFIC AND ORGANIZING COMMITTEE

Cesare Balduini
Luisa Bracci
Paola Bruni
Maria Eugenia Schininà
Vittorio Bellotti
Roberta Besio
Ilaria Canobbio
Sofia Giorgetti
Gianni Guidetti
Giampaolo Minetti
Giampiero Pietrocola
Maria Enrica Tira

 SCIENTIFIC AND ORGANIZING SECRETARIAT

Università degli Studi di Pavia

Dipartimento di Biologia e Biotecnologie “Lazzaro Spallanzani”

Laboratori di Biochimica

Via A. Bassi, 21 – 27100 PAVIA

 Tel. 0382/987236 – Fax 0382/987240

E-mail: riundott@unipv.it  – Homepage: http://www.unipv.it/bralweb

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PROGRAM

MONDAY, JUNE 4^th, 2018

17.00-20.00 ARRIVAL AND REGISTRATION

20.00 DINNER

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The topic of this year will be the managment of oxygen in cells and organisms

TUESDAY, JUNE 5^th, 2018

8.50-9.00 OPENING OF THE MEETING

Chair:    Cesare Balduini

9.00-9.40 Prof. ALESSANDRA PESCE (Genova)
Human globins: from oxygen transport to catalysis

9.40-10.00 Raffaella Longo (Milano)
Histone deacetylase 3 is a regulator of adipose tissue metabolism and of immune cell population

10.00-10.20 Linda Turnu (Milano)
An untargeted metabolomics approach to go beyond aspirin canonical effects

COFFEE BREAK

Chair:    Alessandra Pesce

10.50-11.10 Vaibhav Yellenki (Novara)
Lipid binding domains of atypical PKC

11.10-11.30 Marina Bruno (Siena)
Role of sphingosine 1-phosphate signaling axis in the differentiation of epithelial cochlear progenitors

11.30-11.50 Erika Di Biase (Milano)
The oligosaccharide of GM1 ganglioside as a new neurotrophic agent: evidence on the development of primary neurons in culture

11.50-12.10 Giulia Lunghi (Milano)
GM1 neuroprotective properties are related to GM1 oligosaccharide

LUNCH

Chair:    Linda Turnu / Flavia Giamogante

15.00-15.40 Prof. NICCOLÒ TADDEI (Firenze)
The role of oxidative stress in human pathology

15.40-16.00 Carmen Troiano (Padova)
O-GlcNacylation of F-ATP synthase in relation to mitochondrial ROS formation, diabetes, and PTP opening

16.00-16.20 Maria Elena Canali (Milano)
The role of sialidase NEU3 in the cardiac response to ischemia and reperfusion injury

COFFEE BREAK

17.00-19.00 POSTER PRESENTATION FOLLOWED BY POSTER VIEWING – SESSION A
Authors should place their posters on the provided boards and present them in front of the audience with 2-3 slides for a total of 5 min including discussion.

DINNER

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WEDNESDAY, JUNE 6^th, 2018

Chair:    Anna Bogdanova

9.00-9.40 Prof. HEIMO MAIRBÄURL (Heidelberg)
On Hypoxia inducible factor and protein synthesis as mechanisms to adjust alveolar ion transport to hypoxia

9.40-10.00 Giulia Murtas (Varese)
The biochemistry of human D-amino acid oxidase

10.00-10.20 Roberta Melis (Varese)
Evolution of L-amino acid deaminase activity for biotechnological applications

COFFEE BREAK

Chair:    Niccolò Taddei

10.50-11.10 Matteo Miceli (Milano)
Detecting the activity of the endocannabinoid system catabolic enzymes: an ultrasensitive bioluminescence assay

11.10-11.30 Giulia Mancini (Milano)
Role of ganglioside GM1 as new therapeutic strategy to improve CFTR stability and function at plasma membrane level

11.30-11.50 Matteo Trande (Verona)
Biochemical characterization of calmodulin like protein 7 from Arabidopsis thaliana

11.50-12.10 Flavia Giamogante (Roma)
The effects of the punicalagin and of the non-edible part extract of pomegranates on protein disulfide isomerase 3

LUNCH

Chair:    Matteo Miceli

15.00-15.40 Prof. FRANCESCO FRANCIA (Bologna)
Photosynthetic bacteria: a unique model for dissecting the chain of electronic transport

15.40-16.00 Leila Quercini (Siena)
The peptide SET-M33 as novel agent to neutralize and remove LPS and LTA in patients with sepsis

16.00-16.20 Paolo La Rocca (Milano)
Battle against paramyxoviruses: new and potent hemagglutinin- neuraminidase inhibitors

COFFEE BREAK

Chair:    Francesco Francia

17.00-17.40 Prof. Anna Bogdanova (Zurigo)
Comparative adaptation of RBCs (hemoglobins) to hypoxia

20:00        DINNER

21.00-23.00 Serata caminetto
Prof Claudia Martini e Prof Giovanni Foresti:
Organizzazione dei gruppi di ricerca e conflitti inter-generazionali

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THURSDAY, JUNE 7^th, 2018

Chair:    Giulia Mancini

9.00-9.40 Prof. PAOLO PEDONE (Napoli)
Zinc finger DNA binding proteins: readers and organizers of the genomes in prokaryotes and eukaryotes

9.40-10.00 Stefania Giussani (Pavia)
The Streptococcus agalactiae CIP protein combines multiple complement interference mechanisms by interacting with both C4 and C3 ligands

10.00-10.20 Rossella Costantini (Pavia)
Generation and characterization of an animal model of chondrodysplasia with joint dislocations gPAPP type

COFFEE BREAK

Chair:    Raffaella Longo

10.50-11.10 Giulia Faravelli (Pavia)
Characterization of a C. elegans strain expressing D76N beta-2 microglobulin by automated phenotypic assays: a useful model for drug screening

11.10-11.30 Elena Caravà (Varese)
Vascular inflammation and extracellular matrix modifications

11.30-11.50 Livia Cabitta (Milano)
Identification of the antigen recognized by rHIgM22, a remyelination-promoting human monoclonal antibody

11.50-12.10 Marta Zarà (Pavia)
Tumor cell-induced platelet aggregation: molecular mechanisms and functional consequences

LUNCH

Chair:    Antonio Rossi

15.00-15.40 Prof. JERZY PALKA (Bialystok)
An overview on current advanced pharmacotherapy of cancer and further perspectives

COFFEE BREAK

16.30-18.30 POSTER PRESENTATION FOLLOWED BY POSTER VIEWING – SESSION B
Authors should place their posters on the provided boards and present them in front of the audience with 2-3 slides for a total of 5 min including discussion.

DINNER

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FRIDAY, JUNE 8^th, 2018

Chair:    Vittorio Bellotti

9.30-10.10 Prof. LOREDANO POLLEGIONI (Varese)
Modulation of oxygen reactivity: the way to novel applications

10.15 CLOSING REMARKS

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COFFEE BREAK and DEPARTURE

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POSTER SESSION A, TUESDAY, JUNE 5^th 2018, 17:00-19:00  

1. Francesca Grassi (Milano): Proteomic analysis of PTMS induced by environmental factors in Paracentrotus lividus’ toposome protein
2. Sabrina Fasoli (Verona): Properties of RNAse A monomer and dimers depend on the oligomerization pathway followed
3. Amanda Mannucci (Firenze): Fibrinogen structural and functional alterations in systemic lupus erythematosus (SLE) patients
4. Fabiana Miraglia (Pisa): Developing fret-based biosensors for the detection of alpha synuclein aggregation in living cells
5. Simona Saporiti (Milano): An in silico structural approach to critical quality attributes assessment in biopharmaceutical products
6. Simona Cantarella (Parma): Genome-wide activation of ALU expression by adenovirus small E1A
7. Jessica Canino (Pavia): Tyrosine kinase Pyk2 regulates neutrophil adhesion to fibrinogen
8. Giorgio Cinque (Udine): Suppression of KRAS by G4-decoy oligonucleotides in pancreatic cancer cells
9. Omar De Bei (Parma): Development of a high-throughput assay to identify inhibitors of S. aureus IsdB binding to human hemoglobin
10. Nadia Garibaldi (Pavia): Pathogenesis of osteogenesis imperfecta: the emerging role of intracellular collagen retention
11. Laura Leoni (Pavia): Generation of in vitro and in vivo models of OI type XIV
12. Chiara Manega (Milano): 12-HETE, the neglected platelets 12-LOX product: role in the macrophage efferocytic process
13.  Carolina Peri (Milano): Studying the epigenetic basis of age-related metabolic diseases in humanized mouse models

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POSTER SESSION B, THURSDAY, JUNE 8^th, h 16:30-18:30  

1. Anna Barile (Roma): Role of pyridoxine 5’- phosphate oxidase as pyridoxal 5′-phosphate carrier protein in vitamin B6 metabolism and bioavailability
2. Noemi Bigini (Urbino): Phenylalanine ammonia lyase-loaded erythrocytes as enzyme replacement therapy for phenylketonuria
3. Giovanna Butera (Verona): Mutant p53 proteins trigger chemoresistance stabilizing GAPDH in the cytoplasm of pancreatic cancer cells
4. Roberta Cavagna (Milano): Capture-based next generation sequencing approach improves the immunoglobulin/T cell receptors clonal markers identification in adult acute lymphoblastic leukemia patients lacking molecular probes
5. Lidia Croce (Urbino): The multifaceted effects of the sclerotherapy treatment in chronic venous disease in vitro models
6. Sonia Floris (Cagliari): Inhibitory activity of Washingtonia filifera extracts
7. Ilaria Iacobucci (Napoli): Structural determinants in ApoAI amyloidogenic variants explain improved cholesterol metabolism despite low HDL levels
8. Angela Leo (Siena): Claisened hexafluoro as potential inhibitor of amoeboid motility of melanoma cells
9. Nicla Lorito (Siena): Metabolic reprogramming of ER+ breast cancer in endocrine therapy resistance
10. Caterina Nardella (Roma): Regulation of vitamin B6 salvage pathway in Salmonella typhimurium: involvement of the MocR-like pyridoxal 5’-phosphate-dependent transcriptional regulator PTSJ
11. Silvia Pedretti (Milano): Integrated approaches to investigate the role of the mitochondrial regulator Zc3h10 in adipocytes
12. Sofia Pugnaloni (Ancona): Impact of supplementation with ubiquinol on endothelial function in people at risk of developing cardiovascular diseases
13. Alice Raineri (Verona): Onconase cytotoxicity in melanoma cancer cells: promising results to be enforced by oligomerizing the protein
14. Greta Simionato (Saarbrücken): Characterization of red blood cells in sickle cell disease

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